A role for IL-25 and IL-33–driven type-2 innate lymphoid cells in atopic dermatitis

@inproceedings{Salimi2013ARF,
  title={A role for IL-25 and IL-33–driven type-2 innate lymphoid cells in atopic dermatitis},
  author={Maryam Salimi and Jillian L Barlow and Sean P Saunders and Luzheng Xue and Danuta Gutowska-Owsiak and Xinwen Wang and Li-Chieh Huang and David H. Johnson and Seth Thomas Scanlon and Andrew N. J. McKenzie and Padraic G Fallon and Graham S Ogg},
  booktitle={The Journal of experimental medicine},
  year={2013}
}
Type 2 innate lymphoid cells (ILC2s, nuocytes, NHC) require RORA and GATA3 for their development. We show that human ILC2s express skin homing receptors and infiltrate the skin after allergen challenge, where they produce the type 2 cytokines IL-5 and IL-13. Skin-derived ILC2s express the IL-33 receptor ST2, which is up-regulated during activation, and are… CONTINUE READING