A role for His155 in binding of human prion peptide144-167 to immobilised prion protein.

@article{Hesp2007ARF,
  title={A role for His155 in binding of human prion peptide144-167 to immobilised prion protein.},
  author={J Richard Hesp and Neil D. H. Raven and J. Mark Sutton},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={362 3},
  pages={695-9}
}
The interactions and conformational changes that lead to the conversion of the normal prion protein (PrP(c)) to its pathogenic form, PrP(sc), are still being elucidated. Using Surface Plasma Resonance (SPR), we provide evidence that a synthetic peptide (PrP(144-167)) corresponding to residues comprising the alpha helix 1-beta strand 2 domain of PrP(c) is able to interact and bind to immobilised recombinant human PrP (rHuPrP) in a dose-dependent manner. The interaction is pH dependent with an… CONTINUE READING

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