A role for H3K4 monomethylation in gene repression and partitioning of chromatin readers.

@article{Cheng2014ARF,
  title={A role for H3K4 monomethylation in gene repression and partitioning of chromatin readers.},
  author={Jemmie Cheng and Roy Blum and Christopher John Bowman and Deqing Hu and Ali Shilatifard and Steven R. S. Shen and Brian D. Dynlacht},
  journal={Molecular cell},
  year={2014},
  volume={53 6},
  pages={979-92}
}
Monomethylation of lysine 4 on histone H3 (H3K4me1) is a well-established feature of enhancers and promoters, although its function is unknown. Here, we uncover roles for H3K4me1 in diverse cell types. Remarkably, we find that MLL3/4 provokes monomethylation of promoter regions and the conditional repression of muscle and inflammatory response genes in myoblasts. During myogenesis, muscle genes are activated, lose MLL3 occupancy, and become H3K4-trimethylated through an alternative COMPASS… CONTINUE READING