A role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis.

@article{Wang2009ARF,
  title={A role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis.},
  author={Dong Wang and Biman C. Paria and Qiuhua Zhang and Manjula Karpurapu and Quanyi Li and William T. Gerthoffer and Yoshikazu Nakaoka and G Vamshi Nandan Rao},
  journal={Circulation research},
  year={2009},
  volume={104 9},
  pages={1066-75}
}
To understand the role of epidermal growth factor receptor (EGFR) transactivation in G protein-coupled receptor (GPCR) agonist-induced signaling events, we have studied the capacity of thrombin in the activation of Gab1-SHP2 in vascular smooth muscle cells (VSMCs). Thrombin activated both Gab1 and SHP2 in EGFR-dependent manner. Similarly, thrombin induced Rac1 and Cdc42 activation, and these responses were suppressed when either Gab1 or SHP2 stimulation is blocked. Thrombin also induced PAK1… CONTINUE READING