A role for G-protein coupled estrogen receptor (GPER) in estrogen-induced carcinogenesis: Dysregulated glandular homeostasis, survival and metastasis

@article{Filardo2018ARF,
  title={A role for G-protein coupled estrogen receptor (GPER) in estrogen-induced carcinogenesis: Dysregulated glandular homeostasis, survival and metastasis},
  author={E. Filardo},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2018},
  volume={176},
  pages={38-48}
}
  • E. Filardo
  • Published 2018
  • Biology, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
  • Mechanisms of carcinogenesis by estrogen center on its mitogenic and genotoxic potential on tumor target cells. These models suggest that estrogen receptor (ER) signaling promotes expansion of the transformed population and that subsequent accumulation of somatic mutations that drive cancer progression occur via metabolic activation of cathecol estrogens or by epigenetic mechanisms. Recent findings that GPER is linked to obesity, vascular pathology and immunosuppression, key events in the… CONTINUE READING
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