A role for DNA methylation in regulation of EphA5 receptor expression in the mouse retina

@article{Petkova2011ARF,
  title={A role for DNA methylation in regulation of EphA5 receptor expression in the mouse retina},
  author={Tihomira D. Petkova and Gail M Seigel and Deborah C Otteson},
  journal={Vision Research},
  year={2011},
  volume={51},
  pages={260-268}
}
Understanding the mechanisms regulating expression of retinal ganglion cell (RGC) specific and axon-guidance genes during development and in retinal stem cells will be critical for successful optic nerve regeneration. Müller glia have some characteristics of retinal stem cells but in mammals have demonstrated limited potential to differentiate into RGCs. Chromatin remodeling through histone deacetylation and DNA methylation are a potential mechanism for silencing genes necessary for neuronal… CONTINUE READING