A role for DNA-PK in retroviral DNA integration.

@article{Daniel1999ARF,
  title={A role for DNA-PK in retroviral DNA integration.},
  author={Ren{\'e} Daniel and Richard A. Katz and Anna Marie Ann Skalka},
  journal={Science},
  year={1999},
  volume={284 5414},
  pages={644-7}
}
Retroviral DNA integration is catalyzed by the viral protein integrase. Here, it is shown that DNA-dependent protein kinase (DNA-PK), a host cell protein, also participates in the reaction. DNA-PK-deficient murine scid cells infected with three different retroviruses showed a substantial reduction in retroviral DNA integration and died by apoptosis. Scid cell killing was not observed after infection with an integrase-defective virus, suggesting that abortive integration is the trigger for death… CONTINUE READING

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