A role for DJ-1 against oxidative stress in the mammalian retina

  title={A role for DJ-1 against oxidative stress in the mammalian retina},
  author={Jos{\'e} Mart{\'i}n-Nieto and M. L. Uribe and Juli{\'a}n Esteve-Rudd and Mar{\'i}a Trinidad Herrero and Laura Campello},
  journal={Neuroscience Letters},
We have previously reported the expression of Parkinson disease-associated genes encoding α-synuclein, parkin and UCH-L1 in the retina across mammals. DJ-1, or parkinsonism-associated deglycase, is a redox-sensitive protein with putative roles in cellular protection against oxidative stress, among a variety of functions, acting through distinct pathways and mechanisms in a wide variety of tissues. Its function in counteracting oxidative stress in the retina, as it occurs in Parkinson and other… Expand
6 Citations
DJ-1 alleviates anoxia and hypoglycemia injury in cardiac microvascular via AKT and GSH.
The results indicated that DJ-1 can regulate glutathione (GSH) levels by modulating AKT activity in CMEC with A/H injury via the AKT/GSH signaling pathway. Expand
The Importance of Drosophila melanogaster Research to UnCover Cellular Pathways Underlying Parkinson’s Disease
The different PD models in flies and key findings identified in flies in different affected pathways in PD are discussed, of which mitochondrial dysfunction and a defective endo-lysosomal pathway emerge to be the most relevant for PD pathogenesis. Expand
The retinal pigment epithelium in Sorsby Fundus Dystrophy shows increased sensitivity to oxidative stress-induced degeneration
These studies suggest that TIMP3 mutations may result in a dysregulation of pro-oxidant—antioxidant homeostasis in the RPE, leading to RPE degeneration in SFD. Expand
Red Light Irradiation In Vivo Upregulates DJ-1 in the Retinal Ganglion Cell Layer and Protects against Axotomy-Related Dendritic Pruning
Photobiomodulation (PBM) with red light provided neuroprotection to RGCs when administered ex vivo to wild-type retinal explants, indicating a potential molecular mechanism priming the retina to resist future oxidative insult. Expand
Role of Nuclear Factor Kappa B (NF-KB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach
Regulation of NF- KB signaling pathway may be a safe and effective treatment strategy for various disorders and plays a novel therapeutic target in preventing various diseases. Expand
Anti-apoptotic activity of Chlamydia trachomatis Pgp3 protein involves activation of the ERK1/2 pathway mediated by up-regulation of DJ-1 protein.
Novel insights are provided into the role of Pgp3 in apoptosis and manipulation of the host apoptosis response could be a new approach for the prevention and treatment of C. trachomatis infection. Expand


DJ-1-Dependent Regulation of Oxidative Stress in the Retinal Pigment Epithelium (RPE)
Increased DJ-1 expression prior to oxidative stress leads to decreased generation of ROS, which will be relevant for future studies of AMD since oxidative stress is a known factor affecting this disease. Expand
Expression of DJ-1 in Neurodegenerative Disorders.
This chapter provides an overview on the expression of DJ-1 mRNA and protein in different neurodegenerative disorders and discusses some of its main functions together withDJ-1's potential for neuroprotection. Expand
Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection.
Results may imply that DJ-1 plays an important role in the neuronal defense mechanism against oxidative insults, after exposure of naïve neuroblastoma cells to rotenone or 6-hydroxydopamine induced upregulation ofDJ-1 mRNA and protein levels. Expand
DJ-1 Is a Redox-Dependent Molecular Chaperone That Inhibits α-Synuclein Aggregate Formation
It is demonstrated that DJ-1 functions as a redox-sensitive molecular chaperone that is activated in an oxidative cytoplasmic environment and extends to α-synuclein, a protein implicated in PD pathogenesis. Expand
Expression in the mammalian retina of parkin and UCH-L1, two components of the ubiquitin-proteasome system
The ample distribution of parkin and UCH-L1 in the mammalian retina, together with the crucial role played by the UPS in normal neuronal physiology in the brain, points to a participation of these two proteins in the ubiquitin-proteasomal pathway of protein degradation in most retinal cell types, where they could exert a protective function against neuronal stress. Expand
DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease
Data suggest that direct interactions between DJ-1 and aSyn constitute the basis for a neuroprotective mechanism and that familial mutations inDJ-1 may contribute to PD by disrupting these interactions. Expand
Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis.
It is found that DJ-1 is widely distributed and is highly expressed in the brain and mitochondrial matrix and inter-membrane space and is an integral mitochondrial protein that may have important functions in regulating mitochondrial physiology. Expand
Alterations in Energy Metabolism, Neuroprotection and Visual Signal Transduction in the Retina of Parkinsonian, MPTP-Treated Monkeys
Functional categories underscore that alterations in energy metabolism, neuroprotective mechanisms and signal transduction are involved in MPTP-induced neuronal degeneration in the retina, in similarity to mechanisms thought to underlie neuronal death in the Parkinson’s diseased brain and neurodegenerative diseases of the retina proper. Expand
DJ-1 as a Biomarker of Parkinson's Disease.
  • Y. Saito
  • Medicine
  • Advances in experimental medicine and biology
  • 2017
The properties of DJ-1 and oxDJ-1 levels as a biomarker of Parkinson's disease and the usability of these biomarkers to prevent and treat this neurodegenerative disease are discussed. Expand
PAR2-mediated epigenetic upregulation of α-synuclein contributes to the pathogenesis of Parkinson׳s disease
The results indicated the critical involvement of PAR2-NF-κB signaling in the upregulation of α-synuclein and motor dysfunction in the rodent model of PD, and shed light on the development of novel approaches for the treatment of patients with PD. Expand