A role for CD8+ T lymphocytes in the pathogenesis of AIDS.

@article{ArandaAnzaldo1991ARF,
  title={A role for CD8+ T lymphocytes in the pathogenesis of AIDS.},
  author={A. Aranda-Anzaldo},
  journal={Research in immunology},
  year={1991},
  volume={142 7},
  pages={541-50}
}
Experimental and clinical evidence is presented which supports the hypothesis that CD8+ T lymphocytes aimed at suppressing HIV replication in infected CD4+ T cells may have an important role in the pathogenesis of AIDS by directly causing a decrease in CD4+ T lymphocyte numbers. Possible models to test this hypothesis are discussed.