A role for C. elegans Eph RTK signaling in PTEN regulation.

  title={A role for C. elegans Eph RTK signaling in PTEN regulation.},
  author={Sarah Brisbin and Jun Yong Liu and Jeff R Boudreau and Jimmy Peng and Marie Evangelista and Ian Chin-Sang},
  journal={Developmental cell},
  volume={17 4},
PTEN is one of the most commonly lost tumor suppressors in human cancer and is known to inhibit insulin signaling. Eph receptor tyrosine kinases (RTKs) have also been implicated in cancer formation and progression, and they have diverse functions, including nervous and vascular system development. We show that in C. elegans, the VAB-1 Eph kinase domain physically interacts with and phosphorylates PTEN (DAF-18), diminishing its protein levels and function. vab-1 mutants show increased longevity… CONTINUE READING