A role for ActA in epithelial cell invasion by Listeria monocytogenes.

@article{Surez2001ARF,
  title={A role for ActA in epithelial cell invasion by Listeria monocytogenes.},
  author={Marta Magdalena Su{\'a}rez and B. Gonz{\'a}lez-zorn and Yolanda Vega Vega and Isabel Chico-Calero and Jos{\'e} A V{\'a}zquez-Boland},
  journal={Cellular microbiology},
  year={2001},
  volume={3 12},
  pages={
          853-64
        }
}
We assessed the role of the actin-polymerizing protein, ActA, in host cell invasion by Listeria monocytogenes. An in frame DeltaactA mutant was constructed in a hyperinvasive strain of prfA* genotype, in which all genes of the PrfA-dependent virulence regulon, including actA, are highly expressed in vitro. Loss of ActA production in prfA* bacteria reduced entry into Caco-2, HeLa, MDCK and Vero epithelial cells to basal levels. Reintroduction of actA into the DeltaactA prfA* mutant fully… CONTINUE READING
BETA

Similar Papers

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 48 CITATIONS

ActA of Listeria monocytogenes and Its Manifold Activities as an Important Listerial Virulence Factor.

  • Current topics in microbiology and immunology
  • 2016
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

New insights into determinants of Listeria monocytogenes virulence.

  • International review of cell and molecular biology
  • 2008
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED