A role for ActA in epithelial cell invasion by Listeria monocytogenes.

@article{Surez2001ARF,
  title={A role for ActA in epithelial cell invasion by Listeria monocytogenes.},
  author={Marta Magdalena Su{\'a}rez and Bruno Gonz{\'a}lez-Zorn and Yolanda Vega and Isabel Chico-Calero and Jose Vazquez-Boland},
  journal={Cellular microbiology},
  year={2001},
  volume={3 12},
  pages={
          853-64
        }
}
We assessed the role of the actin-polymerizing protein, ActA, in host cell invasion by Listeria monocytogenes. An in frame DeltaactA mutant was constructed in a hyperinvasive strain of prfA* genotype, in which all genes of the PrfA-dependent virulence regulon, including actA, are highly expressed in vitro. Loss of ActA production in prfA* bacteria reduced entry into Caco-2, HeLa, MDCK and Vero epithelial cells to basal levels. Reintroduction of actA into the DeltaactA prfA* mutant fully… CONTINUE READING
Highly Cited
This paper has 63 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

63 Citations

0510'03'06'10'14'18
Citations per Year
Semantic Scholar estimates that this publication has 63 citations based on the available data.

See our FAQ for additional information.