A role for ActA in epithelial cell invasion by Listeria monocytogenes.

  title={A role for ActA in epithelial cell invasion by Listeria monocytogenes.},
  author={Marta Magdalena Su{\'a}rez and Bruno Gonz{\'a}lez-Zorn and Yolanda Vega and Isabel Chico-Calero and Jose Vazquez-Boland},
  journal={Cellular microbiology},
  volume={3 12},
We assessed the role of the actin-polymerizing protein, ActA, in host cell invasion by Listeria monocytogenes. An in frame DeltaactA mutant was constructed in a hyperinvasive strain of prfA* genotype, in which all genes of the PrfA-dependent virulence regulon, including actA, are highly expressed in vitro. Loss of ActA production in prfA* bacteria reduced entry into Caco-2, HeLa, MDCK and Vero epithelial cells to basal levels. Reintroduction of actA into the DeltaactA prfA* mutant fully… CONTINUE READING
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