A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery.

@article{Liu2006ARF,
  title={A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery.},
  author={Xibao Liu and Bidhan C. Bandyopadhyay and Tetsuji Nakamoto and Brij B. Singh and Wolfgang B Liedtke and James E Melvin and Indu S Ambudkar},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 22},
  pages={15485-95}
}
Regulation of cell volume in response to changes in osmolarity is critical for cell function and survival. However, the molecular basis of osmosensation and regulation of cell volume are not clearly understood. We have examined the mechanism of regulatory volume decrease (RVD) in salivary gland cells and report a novel association between osmosensing TRPV4 (transient receptor potential vanalloid 4) and AQP5 (aquaporin 5), which is required for regulating water permeability and cell volume… CONTINUE READING
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