A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle.

@article{Mu2001ARF,
  title={A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle.},
  author={James Mu and Joseph T. Brozinick and Otto Valladares and Maja Bucan and Morris J Birnbaum},
  journal={Molecular cell},
  year={2001},
  volume={7 5},
  pages={1085-94}
}
Eukaryotic cells possess systems for sensing nutritional stress and inducing compensatory mechanisms that minimize the consumption of ATP while utilizing alternative energy sources. Such stress can also be imposed by increased energy needs, such as in skeletal muscle of exercising animals. In these studies, we consider the role of the metabolic sensor, AMP-activated protein kinase (AMPK), in the regulation of glucose transport in skeletal muscle. Expression in mouse muscle of a dominant… CONTINUE READING
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