A role for 12(S)-HETE in the response of human lens epithelial cells to epidermal growth factor and insulin.


PURPOSE To determine whether the 12-lipoxygenase pathway of arachidonic acid metabolism is present in the human lens and whether 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) plays a role in regulating proto-oncogene expression and DNA synthesis in human lens epithelial cells (HLECs). METHODS Second- and third-passage primary cultures of HLECs were used… (More)


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