A robust genomic signature for the detection of colorectal cancer patients with microsatellite instability phenotype and high mutation frequency#

@inproceedings{Tian2012ARG,
  title={A robust genomic signature for the detection of colorectal cancer patients with microsatellite instability phenotype and high mutation frequency#},
  author={Sun Tian and Paul Roepman and Vlad Popovici and Magali Michaut and Ian J. Majewski and Robinson Salazar and Cristina Maria B. Santos and Robert Rosenberg and Ulrich Nitsche and Wilma E. Mesker and Sjoerd C. Bruin and Sabine Tejpar and Mauro Delorenzi and Ren{\'e} Bernards and Iris M. Simon},
  booktitle={The Journal of pathology},
  year={2012}
}
Microsatellite instability (MSI) occurs in 10-20% of colorectal tumours and is associated with good prognosis. Here we describe the development and validation of a genomic signature that identifies colorectal cancer patients with MSI caused by DNA mismatch repair deficiency with high accuracy. Microsatellite status for 276 stage II and III colorectal tumours has been determined. Full-genome expression data was used to identify genes that correlate with MSI status. A subset of these samples (n… CONTINUE READING
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