A robust and rapid xenograft model to assess efficacy of chemotherapeutic agents for human acute myeloid leukemia

@inproceedings{Saland2015ARA,
  title={A robust and rapid xenograft model to assess efficacy of chemotherapeutic agents for human acute myeloid leukemia},
  author={Estelle Saland and Héléna Boutzen and R Castellano and L Pouyet and Eric Grie{\ss}inger and Christophe Larrue and F de Toni and S Scotland and M D{\'a}vid and Gwenn-ael Danet-Desnoyers and François Vergez and Yara Barreira and Yves Collette and Christian R{\'e}cher and J-E Sarry},
  booktitle={Blood cancer journal},
  year={2015}
}
Relevant preclinical mouse models are crucial to screen new therapeutic agents for acute myeloid leukemia (AML). Current in vivo models based on the use of patient samples are not easy to establish and manipulate in the laboratory. Our objective was to develop robust xenograft models of human AML using well-characterized cell lines as a more accessible and faster alternative to those incorporating the use of patient-derived AML cells. Five widely used AML cell lines representing various AML… CONTINUE READING

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