A robust Bayesian dose-finding design for phase I/II clinical trials.

Abstract

We propose a Bayesian phase I/II dose-finding trial design that simultaneously accounts for toxicity and efficacy. We model the toxicity and efficacy of investigational doses using a flexible Bayesian dynamic model, which borrows information across doses without imposing stringent parametric assumptions on the shape of the dose-toxicity and dose-efficacy… (More)
DOI: 10.1093/biostatistics/kxv040

Topics

5 Figures and Tables

Cite this paper

@article{Liu2016ARB, title={A robust Bayesian dose-finding design for phase I/II clinical trials.}, author={Suyu Liu and Valen E. Johnson}, journal={Biostatistics}, year={2016}, volume={17 2}, pages={249-63} }