A robust, high-sensitivity algorithm for automated detection of proteins in two-dimensional electrophoresis gels

@article{Solomon1993ARH,
  title={A robust, high-sensitivity algorithm for automated detection of proteins in two-dimensional electrophoresis gels},
  author={J. E. Solomon and M. G. Harrington},
  journal={Computer applications in the biosciences : CABIOS},
  year={1993},
  volume={9 2},
  pages={133-9}
}
The automated interpretation of two-dimensional gel electrophoresis images used in protein separation and analysis presents a formidable problem in the detection and characterization of ill-defined spatial objects. We describe in this paper a hierarchical algorithm that provides a robust, high-sensitivity solution to this problem, which can be easily adapted to a variety of experimental situations. The software implementation of this algorithm functions as part of a complete package designed… CONTINUE READING