A-ring oxygenation modulates the chemistry and bioactivity of caged Garcinia xanthones.

@article{Elbel2013AringOM,
  title={A-ring oxygenation modulates the chemistry and bioactivity of caged Garcinia xanthones.},
  author={Kristyna M. Elbel and G. Guizzunti and Maria A. Theodoraki and Jing Xu and Ayse Batova and Marianna Dakanali and Emmanuel A Theodorakis},
  journal={Organic & biomolecular chemistry},
  year={2013},
  volume={11 20},
  pages={3341-8}
}
Natural products of the caged Garcinia xanthones (CGX) family are characterized by a unique chemical structure, potent bioactivities and promising pharmacological profiles. We have developed a Claisen/Diels-Alder reaction cascade that, in combination with a Pd(0)-catalyzed reverse prenylation, provides rapid and efficient access to the CGX pharmacophore, represented by the structure of cluvenone. To further explore this pharmacophore, we have synthesized various A-ring oxygenated analogues of… CONTINUE READING

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