A rifampicin resistance mutation in the rpoB gene confers ppGpp-independent antibiotic production in Streptomyces coelicolor A3(2)

Abstract

In Streptomyces coelicolor A3(2), deletion of relA or a specific mutation in rplK (relC) results in an inability to synthesize ppGpp (guanosine 5′-diphosphate 3′-diphosphate) and impairs production of actinorhodin. We have found that certain rifampicin-resistant (rif) mutants isolated from either relA or relC strains regain the ability to produce… (More)
DOI: 10.1007/s00438-002-0730-1

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