A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses.

@article{Takagi2005ARE,
  title={A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses.},
  author={Hidenori Takagi and Takachika Hiroi and Lijun Yang and Yoshifumi Tada and Yoshikazu Yuki and Kaoru Takamura and Ryotaro Ishimitsu and Hideyuki Kawauchi and Hiroshi Kiyono and F. Takaiwa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 48},
  pages={17525-30}
}
Peptide immunotherapy using multiple predominant allergen-specific T cell epitopes is a safe and promising strategy for the control of type I allergy. In this study, we developed transgenic rice plants expressing mouse dominant T cell epitope peptides of Cry j I and Cry j II allergens of Japanese cedar pollen as a fusion protein with the soybean seed storage protein glycinin. Under the control of the rice seed storage protein glutelin GluB-1 promoter, the fusion protein was specifically… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 72 extracted citations

Production of Monoclonal Antibodies in Transgenic Plants

Yohannes Besufekad, Pandian Malaiyarsa
2017

Similar Papers

Loading similar papers…