A riboswitch-regulated antisense RNA in Listeria monocytogenes.

@article{Mellin2013ARA,
  title={A riboswitch-regulated antisense RNA in Listeria monocytogenes.},
  author={Jeffery R Mellin and Teresa Tiensuu and Christophe B{\'e}cavin and Edith Gouin and J{\"o}rgen Johansson and Pascale Cossart},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 32},
  pages={13132-7}
}
Riboswitches are ligand-binding elements located in 5' untranslated regions of messenger RNAs, which regulate expression of downstream genes. In Listeria monocytogenes, a vitamin B12-binding (B12) riboswitch was identified, not upstream of a gene but downstream, and antisense to the adjacent gene, pocR, suggesting it might regulate pocR in a nonclassical manner. In Salmonella enterica, PocR is a transcription factor that is activated by 1,2-propanediol, and subsequently activates expression of… CONTINUE READING
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