A review on the molecular diagnostics of Lynch syndrome: a central role for the pathology laboratory

Abstract

Lynch syndrome (LS) is caused by mutations in mismatch repair genes and is characterized by a high cumulative risk for the development of mainly colorectal carcinoma and endometrial carcinoma. Early detection of LS is important since surveillance can reduce morbidity and mortality. However, the diagnosis of LS is complicated by the absence of a pre-morbid… (More)
DOI: 10.1111/j.1582-4934.2009.00977.x

Topics

12 Figures and Tables

Cite this paper

@inproceedings{Lier2010ARO, title={A review on the molecular diagnostics of Lynch syndrome: a central role for the pathology laboratory}, author={Margot G F van Lier and Anja Wagner and Monique Esther van Leerdam and Katharina E Biermann and Ernst J Kuipers and Ewout Willem Steyerberg and Hendrikus Jan Dubbink and Winand N. M. Dinjens}, booktitle={Journal of cellular and molecular medicine}, year={2010} }