A review on the efficacy and toxicity of different doxorubicin nanoparticles for targeted therapy in metastatic breast cancer.

@article{Shafei2017ARO,
  title={A review on the efficacy and toxicity of different doxorubicin nanoparticles for targeted therapy in metastatic breast cancer.},
  author={Ayman El-Sayed Shafei and Wesam M. El-Bakly and Ahmed Sobhy and Omar Wagdy and Ahmed Reda and Omar Aboelenin and Amr Marzouk and Khalil El Habak and Randa Mostafa and Mahmoud Ahmed Ali and Mahmoud Mahmoud Abbass Ellithy},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2017},
  volume={95},
  pages={
          1209-1218
        }
}
In metastatic breast cancer (MBC), the conventional doxorubicin (DOX) has various problems due to lack of selectivity with subsequent therapeutic failure and adverse effects. DOX- induced cardiotoxicity is a major problem that necessitates the presence of new forms to decrease the risk of associated morbidity. Nanoparticles (NPs) are considered an important approach to selectively increase drug accumulation inside tumor cells and thus decreasing the associated side effects. Tumor cells develop… CONTINUE READING