A review on genotoxic and mutagenic effects of monoterpenes

  title={A review on genotoxic and mutagenic effects of monoterpenes},
  author={Muhammad Amirul Islam},
  journal={International Journal of Mathematics},
This review sketches genotoxic and mutagenic potentials of monoterpenes, which find outs some important genotoxic, mutagenic as well as non-genotoxic and non-mutagenic monoterpenes. Monoterpenes are the important natural products. 
1 Citations
Toxic effect and genotoxicity of carvacrol ethers in Drosophila melanogaster.
Among all tested compounds, carvacrol exhibited the most significant impact on frequency of dominant lethal mutations, fecundity and insect survival when inhaled or adding to the culture medium. Expand


Toxaphene, a complex mixture of polychloroterpenes and a major insecticide, is mutagenic.
Toxaphene, the most widely used chlorinated insecticide, is mutagenic in the Salmonella test without requiring liver homogenate for activity. This insecticide is a complex mixture (more than 177Expand
Safety Promises of Diterpenes Concerning on Toxicogenetic Effects
It is doubtless that, the safety assessment for any substance is a lengthy process. Otherwise, lab setup and suitable test system relevant towards the human physiology are the two most common burningExpand
Bacterial mutagenicity of the tranquilizing constituents of Valerianaceae roots.
The valepotriates developed mutagenic activity in these test systems only in the presence of S9 mix, whereas both baldrinals showedmutagenic effects in both tests with and without metabolic activation. Expand
Evaluation of the mutagenicity and genotoxic potential of carvacrol and thymol using the Ames Salmonella test and alkaline, Endo III- and FPG-modified comet assays with the human cell line Caco-2.
Investigation of the potential mutagenicity and genotoxicity of carvacrol and thymol, major compounds in several essential oils, using the Ames Salmonella test and the alkaline, Endo III- and formamidopyrimidine glycosylase (FPG)-modified comet assays shows damage to the purine bases. Expand
Mutagenicity and antimutagenicity testing of six chemicals associated with the pungent properties of specific spices as revealed by the Ames Salmonella/microsomal assay
  • A. Azizan, R. Blevins
  • Chemistry, Medicine
  • Archives of environmental contamination and toxicology
  • 1995
It was inferred that chlorophyll can successfully suppress the mutagenicity activities of capsaicin and 2-aminoanthracene, together with other antimutagenic factors that were present in the acetone extract of C. annum. Expand
Genotoxicity of lavender oil, linalyl acetate, and linalool on human lymphocytes in vitro
It is suggested that the mutagenic activity of lavender oil can be related to the presence of linalyl acetate, which seems to have a profile of an aneugenic agent. Expand
Evaluation of the mutagenicity of beta-myrcene in mammalian cells in vitro.
In vitro results show that the terpene beta-myrcene is not mutagenic in mammalian cells, but has antimutagenic properties and the possibility that myrcene exerts its antimUTagenic activity by inhibiting certain forms of the cytochrome P-450 isoenzymes required for activation of premutagens and precarcinogenes is discussed. Expand
Compounds Combining Aminoadamantane and Monoterpene Moieties: Cytotoxicity and Mutagenic Effects.
A series of secondary amines combining monoterpenoid and aminoadamantane moieties have been synthesized and do not exert the genotoxic effect on cells of the biosensor strain based on recombinant E. coli cells bearing the pRAC-gfp plasmid. Expand
Assessment of the in vitro and in vivo genotoxicity of extracts and indole monoterpene alkaloid from the roots of Galianthe thalictroides (Rubiaceae).
  • L. M. Fernandes, W. Garcez, +4 authors Z. R. Guterres
  • Biology, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2013
The ethanol extract was shown to be genotoxic to HB descendants in the SMART assay, while the results obtained in this test for the monoterpene indole alkaloid 1 isolated from this extract indicated that the aqueous extract had no genotoxicity activity. Expand
Study of cytotoxic, genotoxic and DNA-protective effects of selected plant essential oils on human cells cultured in vitro.
The cytotoxic effects of selected components of essential plant oils on human hepatoma HepG2 and colonic Caco-2 cells were not associated with a DNA-damaging effect and the observed DNA-protective effects of these plant volatiles can be associated with their antioxidant activity. Expand