A review of valproate in psychiatric practice

@article{Haddad2009ARO,
  title={A review of valproate in psychiatric practice},
  author={P. Haddad and Amlan Das and M. Ashfaq and A. Wieck},
  journal={Expert Opinion on Drug Metabolism & Toxicology},
  year={2009},
  volume={5},
  pages={539 - 551}
}
  • P. Haddad, Amlan Das, +1 author A. Wieck
  • Published 2009
  • Medicine
  • Expert Opinion on Drug Metabolism & Toxicology
  • Valproate (2-propylpentanoate) is available as valproic acid, sodium valproate and semisodium valproate. It has actions on dopamine, GABA and glutamate neurotransmission and intracellular signaling. Its main psychiatric use is to treat bipolar disorder. It has been used in other psychiatric disorders, including schizophrenia and borderline personality disorder, but data are insufficient to recommend this. In acute mania, valproate monotherapy has similar efficacy to antipsychotic drugs and… CONTINUE READING
    59 Citations
    Valproate-Related Hyperammonemic Encephalopathy: Report of 1 Case
    • 1
    Valproic Acid for Treatment of Hyperactive or Mixed Delirium: Rationale and Literature Review.
    • 30
    • Highly Influenced
    Adverse drug reactions induced by valproic acid.
    • 176
    Managing the side effects associated with commonly used treatments for bipolar depression.
    • D. Kemp
    • Medicine
    • Journal of affective disorders
    • 2014
    • 43
    Valproic Acid Overdose Review of a Case With Electrocardiographic Changes.
    • A. Muñiz
    • Medicine
    • The Journal of emergency medicine
    • 2017
    Bipolar Depression: Overview and Commentary
    • 121
    Borderline personality disorder: current drug treatments and future prospects
    • 11
    Valproic acid inhibits TTX-resistant sodium currents in prefrontal cortex pyramidal neurons.
    • 9
    Phase I trial of valproic acid and lenalidomide in patients with advanced cancer
    • 18

    References

    SHOWING 1-10 OF 125 REFERENCES
    The history of valproate in clinical neuroscience.
    • T. Henry
    • Medicine
    • Psychopharmacology bulletin
    • 2003
    • 98
    • PDF
    Pharmacological and Therapeutic Properties of Valproate
    • 542
    • Highly Influential
    Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy.
    • 358
    Efficacy of valproate maintenance in patients with bipolar disorder and alcoholism: a double-blind placebo-controlled study.
    • 232
    • PDF
    Valproic Acid Toxicity: Overview and Management
    • 177
    Divalproex in the treatment of bipolar depression: a placebo-controlled study.
    • 161