A review of valproate in psychiatric practice

@article{Haddad2009ARO,
  title={A review of valproate in psychiatric practice},
  author={Peter M. Haddad and Amlan Das and Muhammad Waqas Ashfaq and Angelika Wieck},
  journal={Expert Opinion on Drug Metabolism \& Toxicology},
  year={2009},
  volume={5},
  pages={539 - 551}
}
Valproate (2-propylpentanoate) is available as valproic acid, sodium valproate and semisodium valproate. It has actions on dopamine, GABA and glutamate neurotransmission and intracellular signaling. Its main psychiatric use is to treat bipolar disorder. It has been used in other psychiatric disorders, including schizophrenia and borderline personality disorder, but data are insufficient to recommend this. In acute mania, valproate monotherapy has similar efficacy to antipsychotic drugs and… 
Valproate-Related Hyperammonemic Encephalopathy: Report of 1 Case
TLDR
Valproic acid (sodium valproate, VPA) is the most commonly used antiepileptic drug today in the treatment of epilepsy, and it is also effective in bipolar disorders.
Prescription of Valproate-Containing Medicines in Women of Childbearing Potential who have Psychiatric Disorders: Is It Worth the Risk?
TLDR
This review highlights recent recommendations from influential regulatory and advisory bodies, summarises the relative efficacy and tolerability of valproate preparations in the psychiatric conditions for which they have often been prescribed, and offers practical guidance for the withdrawal and replacement ofValproate-containing medicines in women with psychiatric disorders.
Valproic Acid in the Management of Delirium.
TLDR
VPA is being used more frequently for Delirium and there is a need for RCT to evaluate the effect of VPA in delirium compared to other alternatives and placebo.
The Effect of Valproic Acid on Olanzapine Serum Concentration: A Study Including 2791 Patients Treated With Olanzapine Tablets or Long-Acting Injections.
TLDR
Findings show that the VPA-olanzapine interaction involves a presystemic mechanism and is therefore restricted to oral olanzAPine treatment, whereas for LAI-treated patients fewer precautions are required from a pharmacokinetic point of view.
Long-Term Treatment of Bipolar Disorder with Valproate: Updated Systematic Review and Meta-analyses
TLDR
Valproate was more effective than placebo in preventing new BD episodes of mania or depression, and not significantly different from lithium, second-generation antipsychotics, or other anticonvulsants.
Chronic Valproic Acid Administration Increases Plasma, Liver, and Brain Ammonia Concentration and Suppresses Glutamine Synthetase Activity
TLDR
Results suggest that VPA-induced elevation in plasma NH4 concentration could be related, at least in part, to the suppression of GS activity in liver and brain tissues.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 125 REFERENCES
The history of valproate in clinical neuroscience.
  • T. Henry
  • Medicine
    Psychopharmacology bulletin
  • 2003
TLDR
While pharmacokinetic studies appear definitive, completion of comprehensive pharmacodynamic investigations of valproate's biochemical actions and clinical utility is yet to be achieved.
Pharmacological and Therapeutic Properties of Valproate
TLDR
Valproate is generally regarded as a first-choice agent for most forms of idiopathic and symptomatic generalised epilepsies, and prescription of a broad-spectrum drug such as valproate has clear advantages in this situation.
Effectiveness of valproic acid on destructive and aggressive behaviours in patients with acquired brain injury.
TLDR
The striking efficacy of valproic acid is described and graphically depict in reducing and improving destructive and aggressive behaviours in five patients with acquired brain injury.
Gabapentin in bipolar disorder: a placebo-controlled trial of adjunctive therapy. Gabapentin Bipolar Disorder Study Group.
TLDR
The findings of this study did not demonstrate that gabapentin is an effective adjunctive treatment when administered to outpatients with bipolar disorder.
Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy.
TLDR
By the experimental observations summarised in this review, most clinical effects of valproate can be explained, although much remains to be learned at a number of different levels about the mechanisms of action of Valproate.
Efficacy of valproate maintenance in patients with bipolar disorder and alcoholism: a double-blind placebo-controlled study.
TLDR
The results of this study indicate the potential clinical utility of the anticonvulsant mood stabilizer, valproate, in bipolar disorder with co-occurring alcohol dependence.
Effect of Divalproex Combined with Olanzapine or Risperidone in Patients with an Acute Exacerbation of Schizophrenia
TLDR
Treatment with divalproex in combination with an atypical antipsychotic agent resulted in earlier improvements in a range of psychotic symptoms among acutely hospitalized patients with schizophrenia.
Valproic Acid Toxicity: Overview and Management
TLDR
The pharmacology and toxicology of valproic acid toxicity is reviewed and the use of controversial adjunctive therapies, including extracorporeal drug elimination and l-carnitine supplementation, will be discussed.
Divalproex in the treatment of bipolar depression: a placebo-controlled study.
Valproate as an adjunct to neuroleptic medication for the treatment of acute episodes of mania: a prospective, randomized, double-blind, placebo-controlled, multicenter study. European Valproate Mania Study Group.
TLDR
The combination of neuroleptic and valproate proved superior to neuroleptics in attempts to alleviate manic symptoms, andValproate represents a useful adjunct medication for the treatment of acute manic symptoms.
...
1
2
3
4
5
...