A review of valproate in psychiatric practice

  title={A review of valproate in psychiatric practice},
  author={P. Haddad and Amlan Das and M. Ashfaq and A. Wieck},
  journal={Expert Opinion on Drug Metabolism & Toxicology},
  pages={539 - 551}
  • P. Haddad, Amlan Das, +1 author A. Wieck
  • Published 2009
  • Medicine
  • Expert Opinion on Drug Metabolism & Toxicology
  • Valproate (2-propylpentanoate) is available as valproic acid, sodium valproate and semisodium valproate. It has actions on dopamine, GABA and glutamate neurotransmission and intracellular signaling. Its main psychiatric use is to treat bipolar disorder. It has been used in other psychiatric disorders, including schizophrenia and borderline personality disorder, but data are insufficient to recommend this. In acute mania, valproate monotherapy has similar efficacy to antipsychotic drugs and… CONTINUE READING
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