A review of topoisomerase inhibition in lung cancer.

  title={A review of topoisomerase inhibition in lung cancer.},
  author={Hatim Chhatriwala and Nazia Jafri and Ravi Salgia},
  journal={Cancer biology & therapy},
  volume={5 12},
Lung cancer is the leading cause of cancer deaths among both males and females. Although there have been several advances in the treatment armamentarium, both small cell and nonsmall cell lung cancer continue to be prognostically poor diseases that are refractory to therapy. Several of the regimens involved in treating the disease include drugs that inhibit the topoisomerase enzymes, whose specific role in relieving torsional strain on DNA to facilitate replication and transcription has long… CONTINUE READING