A review of topical high‐concentration L‐menthol as a translational model of cold allodynia and hyperalgesia

@article{Andersen2014ARO,
  title={A review of topical high‐concentration L‐menthol as a translational model of cold allodynia and hyperalgesia},
  author={Hjalte Holm Andersen and Rasmus Vinther Olsen and Heidi Guldborg M{\o}ller and Peter Winther Eskelund and Parisa Gazerani and Lars Arendt-Nielsen},
  journal={European Journal of Pain},
  year={2014},
  volume={18}
}
Cold allodynia and cold hyperalgesia are both elusive features of neuropathic pain, particularly in patients with various polyneuropathies. Numerous studies have suggested that topical application of L‐menthol causes temporary cold hypersensitivity and thus acts as a proxy for associated symptoms. This review summarizes studies on L‐menthol‐induced nociception, cold allodynia and cold hyperalgesia in vitro, in animals and in humans. 
Impact of suggestion on the human experimental model of cold hyperalgesia after topical application of high‐concentration menthol [40%]
TLDR
The objective of this study was to evaluate the impact of suggestion on this experimental human pain model and found that topical application of 40% menthol is suitable to induce cold hyperalgesia.
Somatosensory and vasomotor manifestations of individual and combined stimulation of TRPM8 and TRPA1 using topical L‐menthol and trans‐cinnamaldehyde in healthy volunteers
TLDR
This study investigated the interaction between TRPM8 and TRPA1 receptors through stimulation of glabrous human skin (volar forearm) by topical administration of 40% L‐menthol and 10% trans‐cinnamaldehyde (CA) individually and in combination.
Cold and L-menthol-induced sensitization in healthy volunteers—a cold hypersensitivity analogue to the heat/capsaicin model
TLDR
It is proposed that cold/menthol enhances or prolong L-menthol-evoked sensitization, and this model may prove beneficial for testing analgesic compounds when a sufficient duration of time is needed to see drug effects on CPT or mechanical hypersensitivity.
High-Concentration L-Menthol Exhibits Counter-Irritancy to Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde.
TLDR
It is shown that the frequently used topical counterirritant and TRPM8 agonist, L-menthol, decreased evoked pain, hyperalgesia, and inflammation, indicating direct and indirect antinociceptive mechanisms.
The role and mechanism of action of menthol in topical analgesic products
TLDR
A modern understanding of the molecular mechanism of action of Menthol could form the basis for generating targets for discovery of novel non‐opioid analgesic drugs.
Low-level laser therapy alleviates mechanical and cold allodynia induced by oxaliplatin administration in rats
TLDR
LLLT relieved both cold and mechanical allodynia induced by oxaliplatin in rats and suggested that SP, TRPM8, and NGF proteins in the superficial dorsal horn and DRG may be involved in an antiallodynic effect for LLLT.
l-Menthol attenuates the magnitude of cold-induced vasodilation on the extremities of young females
TLDR
It is suggested that substantial and conductive heat loss through the skin along with activation of cold receptors may be required to retain rewarming at a certain level.
Antipruritic Effect of Cold-induced and Transient Receptor Potential-agonist-induced Counter-irritation on Histaminergic Itch in Humans.
TLDR
Cold-induced counter-irritation had an inhibitory effect on histaminergic itch, suggesting that agonists of cold transduction receptors could be of potential antipruritic value.
Cutaneous Penetration-Enhancing Effect of Menthol: Calcium Involvement.
TLDR
Findings strongly support the involvement of calcium in the penetration-enhancing effect of menthol.
Itching for an answer: A review of potential mechanisms of scalp itch in psoriasis
TLDR
The mast cell is portrayed as one of the main itch conductors for its ability to trigger neurogenic inflammation, activate the peripheral hypothalamic‐pituitary‐adrenal‐axis, process and integrate itch signalling through its interactions with the scalp hair follicles.
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TLDR
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TLDR
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TLDR
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