• Corpus ID: 36920275

A review of three systemic retinoids in dermatology: acitretin, isotretinoin and bexarotene

@inproceedings{Hossein2013ARO,
  title={A review of three systemic retinoids in dermatology: acitretin, isotretinoin and bexarotene},
  author={Mortazavi Seyed Hossein and Aghazadeh Nessa and Ghiasi Maryam and Lajevardi Vahideh},
  year={2013}
}
Retinoids are synthetic and natural analogues of vitamin A that have various effects on cellular differentiation, cellular proliferation, immune system, and embryonic development. The present study reviews the history of systemic retinoids in medicine, the structure of syn 

Tables from this paper

ROLE OF SYSTEMIC RETINOIDS IN THE TREATMENT OF WARTS

TLDR
Systemic retinoids are effective in the treatment of warts and they are well tolerated, non-invasive alternative modalities with few adverse effects.

Retinoids – mechanism of action and range of side effects after oral and topical administration

TLDR
The aim of the study was to show the problems in which retinoids are used in dermatology and cosmetology, the way they work and the indication of possible side effects.

TOPICAL SUBSTITUTION OF TRANSGLUTAMINASE 1 FOR THE TREATMENT OF CONGENITAL ICHTHYOSIS

TLDR
The fate of the protein-loaded thermoresponsive PNIPAM-dPG nanogel for cutaneous protein TGase1 delivery for restoring the skin barrier function in ARCI patients with TGM1 mutation is studied.

Possible Side Effects of Isotretinoin Use in Dermatology: Review Article

TLDR
Assessment of side effects of isotretinoin use in dermatology found that the drug is not without its share of negative side effects, and it is crucial to obtain thorough informed consent from patients and to counsel and follow them closely.

References

SHOWING 1-10 OF 160 REFERENCES

Vitamin E does not reduce the side‐effects of isotretinoin in the treatment of acne vulgaris

TLDR
This data indicates that addition of vitamin E decreased the toxicity of high‐dose retinoids in patients with severe, recalcitrant, nodular acne.

Retinoids: A Clinician's Guide

TLDR
This work describes the mechanism of Retinoid Action in the Skin and the pharmacokinetics of Oral Retinoids in Clinical Practice, as well as investigating their application to Psoriasis.

Possible benefit of oral alitretinoin in T‐lymphoproliferative diseases: a report of two patients with palmoplantar hyperkeratotic‐rhagadiform skin changes and mycosis fungoides or Sézary syndrome

TLDR
It is recommended that screening and treatment for dyslipidaemia may be considered in future guidelines on pemphigus management and therapy, because of the association with diabetes and concomitant treatment with corticosteroids.

Acitretin in psoriasis: an overview of adverse effects.

Systemic isotretinoin in the treatment of rosacea – doxycycline‐ and placebo‐controlled, randomized clinical study

Background: Systemic isotretinoin has been known for decades to be effective in the treatment of severe forms of rosacea, but it must be used off‐label because of the lack of evidence‐based data.

The development of retinoids in experimental and clinical oncology and dermatology.

  • W. Bollag
  • Medicine
    Journal of the American Academy of Dermatology
  • 1983

Isotretinoin‐Induced Agranulocytosis

TLDR
The case of a 15‐year‐old female patient who exhibited agranulocytosis after the initiation of isotretinoin administration is reported, indicating a rare but life‐threatening side effect of isot retinoin use.

Childhood Generalized Pustular Psoriasis: Successful Treatment with Isotretinoin

TLDR
A 16‐year‐old girl with pustular psoriasis with isotretinoin is treated with excellent outcome, and the concern of the long term teratogenetic effect of acitretin in females of childbearing age is raised.

Isotretinoin vs etretinate therapy in generalized pustular and chronic psoriasis.

TLDR
Isotretinoin was found to be less effective than etretinate in the treatment of chronic plaque psoriasis.

Efficiency of acitretin in the treatment of cutaneous lupus erythematosus.

TLDR
It is concluded that acitretin is a highly effective and well-tolerated drug in the treatment of cutaneous lupus erythematosus.
...