A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods

@inproceedings{Madrigal2014ARO,
  title={A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods},
  author={Marialaura Madrigal and Kosagisharaf S Rao and Neil H. Riordan},
  booktitle={Journal of Translational Medicine},
  year={2014}
}
The mesenchymal stem cell (MSC) is being broadly studied in clinical trials. Contrary to the early paradigm of cell replacement and differentiation as a therapeutic mechanism of action, evidence is mounting that the secretions of the cells are responsible for their therapeutic effects. These secretions include molecules and extracellular vesicles that have both local and distant effects. This review summarizes the up- and down-regulation of MSC anti-inflammatory, immune modulating, anti-tumor… CONTINUE READING
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