A review of therapeutic challenges and achievements of methotrexate delivery systems for treatment of cancer and rheumatoid arthritis

@article{Abolmaali2012ARO,
  title={A review of therapeutic challenges and achievements of methotrexate delivery systems for treatment of cancer and rheumatoid arthritis},
  author={Samira Sadat Abolmaali and Ali Mohammad Tamaddon and Rassoul Dinarvand},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2012},
  volume={71},
  pages={1115-1130}
}
Methotrexate (MTX) is one of the most widely studied and effective therapeutics agents available to treat many solid tumors, hematologic malignancies, and autoimmune diseases such as rheumatoid arthritis; however, the poor pharmacokinetic and narrow safety margin of the drug limits the therapeutic outcomes of conventional drug delivery systems. For an improved delivery of MTX, several pathophysiological features such as angiogenesis, enhanced permeability and retention effects, acidosis, and… CONTINUE READING
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