A review of the use of modafinil for attention-deficit hyperactivity disorder

@article{Turner2006ARO,
  title={A review of the use of modafinil for attention-deficit hyperactivity disorder},
  author={Danielle Turner},
  journal={Expert Review of Neurotherapeutics},
  year={2006},
  volume={6},
  pages={455 - 468}
}
  • Danielle Turner
  • Published 1 April 2006
  • Psychology, Medicine
  • Expert Review of Neurotherapeutics
Modafinil (Provigil™) is a novel wakefulness-promoting agent that has been shown to have greater efficacy than placebo in the treatment of attention-deficit hyperactivity disorder (ADHD) in children and adults. In particular, three large, drug-company sponsored trials of a film-coated formulation of modafinil (modafinil-ADHD; Sparlon™) in children and adolescents with ADHD demonstrated consistent improvements in ADHD symptoms compared with placebo. Mean reductions in symptom ratings (measured… 

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References

SHOWING 1-10 OF 121 REFERENCES

Effects of modafinil in children with attention-deficit/hyperactivity disorder: an open-label study.

Modafinil may be a useful once-daily treatment for children with ADHD and a double-blind, placebo-controlled design is needed.

Efficacy of modafinil compared to dextroamphetamine for the treatment of attention deficit hyperactivity disorder in adults.

  • F. TaylorJ. Russo
  • Psychology, Medicine
    Journal of child and adolescent psychopharmacology
  • 2000
Modafinil may be a viable alternative to conventional stimulants for the treatment of adults with ADHD and scores on the DSM-IV ADHD Checklist were significantly improved over the placebo condition following treatment with both active medications.

Non-Stimulant Treatment of Attention-Deficit/Hyperactivity Disorder

Clinical guidelines for each of these agents, as well as their use in combination with stimulants in comorbid conditions, will be discussed.

Efficacy and Safety of Modafinil Film–Coated Tablets in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder: Results of a Randomized, Double-Blind, Placebo-Controlled, Flexible-Dose Study

Intention-to-treat analysis (ITT) showed that compared with placebo, treatment with modafinil significantly improved the core symptoms of ADHD as shown by greater reductions in the ADHD-RS-IV School Version total scores from baseline to final visit.

A Prospective Trial of Modafinil as an Adjunctive Treatment of Major Depression

Preliminary evidence indicates that modafinil may improve fatigue and excessive sleepiness associated with a variety of conditions and may be a useful and a well-tolerated adjunctive agent to standard antidepressants in the treatment of major depression.

Double-blind, placebo-controlled study of modafinil for fatigue and cognition in schizophrenia patients treated with psychotropic medications.

Fatigue improved in both modafinil and placebo groups, and there were no differences between groups on changes in fatigue, symptoms, attention, working memory, or executive functioning.

New drugs for the treatment of attention-deficit/hyperactivity disorder

Atatoxetine, a selective noradrenergic re-uptake inhibitor, is the first non-stimulant compound to receive FDA approval for paediatric and adult ADHD.

Modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder: results of a randomized, double-blind, placebo-controlled, fixed-dose study followed by abrupt discontinuation.

Modafinil significantly improved symptoms of ADHD both at school and at home and was well tolerated by children and adolescents.
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