A review of the use of adjunctive therapies in severe acute asthma exacerbation in critically ill children

  title={A review of the use of adjunctive therapies in severe acute asthma exacerbation in critically ill children},
  author={J. Wong and J. H. Lee and D. Turner and Kyle J. Rehder},
  journal={Expert Review of Respiratory Medicine},
  pages={423 - 441}
  • J. Wong, J. H. Lee, +1 author Kyle J. Rehder
  • Published 2014
  • Medicine
  • Expert Review of Respiratory Medicine
  • Asthma is a common and potentially life threatening childhood condition. Asthma involves not only chronic airway remodeling, but may also include frequent exacerbations resulting from bronchospasm, edema, and mucus production. In children with severe exacerbations, standard therapy with β2-agonists, anti-cholinergic agents, oxygen, and systemic steroids may fail to reverse the severe airflow obstruction and necessitate use of adjunctive therapies. These therapies include intravenous or inhaled… CONTINUE READING
    23 Citations
    Adjunct Therapies for Refractory Status Asthmaticus in Children
    • 26
    • PDF
    Controversies in the Care of the Acute Asthmatic in the Prehospital and Emergency Department Environments
    • J. Tennyson
    • Medicine
    • Current Emergency and Hospital Medicine Reports
    • 2015
    Refractory Status Asthmaticus: A Case for Unconventional Therapies
    Guideline on management of the acute asthma attack in children by Italian Society of Pediatrics
    • 4
    Enoximone in status asthmaticus
    • 2
    • PDF
    Extracorporeal carbon dioxide removal for acute hypercapnic respiratory failure
    • 3
    Management of asthma exacerbation in the emergency departments
    • 5


    Ketamine for management of acute exacerbations of asthma in children.
    • 40
    Use of ketamine in asthmatic children to treat respiratory failure refractory to conventional therapy
    • 94
    • Highly Influential
    Inhalational anesthetics in acute severe asthma.
    • 15
    • Highly Influential
    Intravenous magnesium sulphate in the management of moderate to severe acute asthmatic children nonresponding to conventional therapy.
    • 60
    Isoflurane therapy for severe refractory status asthmaticus in children
    • 73
    Inhaled magnesium sulfate in the treatment of acute asthma.
    • 90
    • PDF
    Gas exchange response to intravenous aminophylline in patients with a severe exacerbation of asthma.
    • 22
    • PDF
    Intravenous beta(2)-agonists versus intravenous aminophylline for acute asthma.
    • 23
    Intravenous aminophylline for acute severe asthma in children over two years receiving inhaled bronchodilators.
    • 71
    A randomized trial of magnesium in the emergency department treatment of children with asthma.
    • 110
    • PDF