A review of the role of the gut microflora in irritable bowel syndrome and the effects of probiotics

@article{Madden2002ARO,
  title={A review of the role of the gut microflora in irritable bowel syndrome and the effects of probiotics},
  author={Jennifer A. J. Madden and John O. Hunter},
  journal={British Journal of Nutrition},
  year={2002},
  volume={88},
  pages={s67 - s72}
}
Irritable bowel syndrome (IBS) is a multi-factorial gastrointestinal condition affecting 8–22 % of the population with a higher prevalence in women and accounting for 20–50 % of referrals to gastroenterology clinics. It is characterised by abdominal pain, excessive flatus, variable bowel habit and abdominal bloating for which there is no evidence of detectable organic disease. Suggested aetiologies include gut motility and psychological disorders, psychophysiological phenomena and colonic… 

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A clear delineation of a postinfective variety of irritable bowel syndrome (IBS), and the description of evidence of low-grade inflammation and immune activation in IBS, suggest a role for a dysfunctional relationship between the indigenous flora and the host in Ibs and provide a clear rationale for the use of probiotics in this disorder.
...

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