A review of the relevance and validity of olfactory bulbectomy as a model of depression

@article{Harkin2003ARO,
  title={A review of the relevance and validity of olfactory bulbectomy as a model of depression},
  author={Andrew Harkin and John Paul Kelly and Brian E. Leonard},
  journal={Clinical Neuroscience Research},
  year={2003},
  volume={3},
  pages={253-262}
}
Development of valid animal models for human affective disorder. Attempts have involved numerous approaches such as the exploitation of vulnerability factors for depression including maternal deprivation, exposure to psychophysiological stress or by pharmacological depletion of monoamines. However, no approach is perhaps so radical as the removal of a part of the brain as occurs in the olfactory bulbectomy (OB) model of depression. The ensuing behavioural symptoms also distinguish the OB model… CONTINUE READING

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