A review of the potential role of methylnaltrexone in opioid bowel dysfunction.

@article{Foss2001ARO,
  title={A review of the potential role of methylnaltrexone in opioid bowel dysfunction.},
  author={Joseph F. Foss},
  journal={American journal of surgery},
  year={2001},
  volume={182 5A Suppl},
  pages={19S-26S}
}
Opioids are widely used analgesics in patients with advanced cancer. However, their effectiveness for pain relief is often limited by the most frequently occurring side effect, opioid bowel dysfunction (OBD). Because conventional laxation measures are often ineffective in treating OBD, alternative approaches need to be investigated. Opioid action on the gut appears to be mediated mainly by receptors in the gastrointestinal (GI) tract rather than by those in the central nervous system (CNS… CONTINUE READING