A review of the pharmacokinetics, tolerability and pharmacodynamics of amisulpride in healthy volunteers

@article{Rosenzweig2002ARO,
  title={A review of the pharmacokinetics, tolerability and pharmacodynamics of amisulpride in healthy volunteers},
  author={Pierre Rosenzweig and M. Canal and Alain A. Patat and Luc Bergougnan and I. Zieleniuk and Gabrio Bianchetti},
  journal={Human Psychopharmacology: Clinical and Experimental},
  year={2002},
  volume={17}
}
Amisulpride binds selectively to dopamine D2 and D3 receptors in the limbic system. Low doses of amisulpride preferentially block presynaptic D2/D3‐dopamine autoreceptors, thereby enhancing dopaminergic transmission, whereas higher doses block postsynaptic receptors, thus inhibiting dopaminergic hyperactivity. Amisulpride is clinically effective on the negative symptoms of acute schizophrenia exacerbations at low dosages (50–300 mg/day), and also on the positive symptoms of the disease at high… Expand
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