A review of the modulation of the startle reflex by affective states and its application in psychiatry

  title={A review of the modulation of the startle reflex by affective states and its application in psychiatry},
  author={C. Grillon and J. Baas},
  journal={Clinical Neurophysiology},
  • C. Grillon, J. Baas
  • Published 2003
  • Psychology, Medicine
  • Clinical Neurophysiology
  • OBJECTIVE To provide an overview of startle reflex methodologies applied to the examination of emotional and motivational states in humans and to review the findings in different forms of psychopathology. METHODS Pertinent articles were searched mostly via MEDLINE and PsycINFO. RESULTS The startle reflex is a non-invasive translational tool of research that bridges the gap between animal and human investigations. Startle is used to study fear and anxiety, affective disturbances… CONTINUE READING
    506 Citations
    Startle response in Generalized Anxiety Disorder
    • 49
    Multilevel impact of the dopamine system on the emotion-potentiated startle reflex
    • 11
    • Highly Influenced
    Clarifying domains of internalizing psychopathology using neurophysiology.
    • 60
    • Highly Influenced
    Psychophysiology in the study of psychological trauma: where are we now and where do we need to be?
    • 9
    • Highly Influenced
    Affective modulation of the startle response among children at high and low risk for anxiety disorders.
    • 13
    • Highly Influenced
    • PDF
    Models and mechanisms of anxiety: evidence from startle studies
    • C. Grillon
    • Psychology, Medicine
    • Psychopharmacology
    • 2007
    • 340
    • PDF


    Fear-potentiated startle in posttraumatic stress disorder
    • 208
    Emotion, attention, and the startle reflex.
    • 2,059
    Startle modulation in children at risk for anxiety disorders and/or alcoholism.
    • 131
    Startle reactivity and anxiety disorders: aversive conditioning, context, and neurobiology
    • C. Grillon
    • Medicine, Psychology
    • Biological Psychiatry
    • 2002
    • 446
    • PDF
    Startle potentiation by threat of aversive stimuli and darkness in adolescents: a multi-site study.
    • C. Grillon, K. Merikangas, +6 authors C. Nelson
    • Psychology, Medicine
    • International journal of psychophysiology : official journal of the International Organization of Psychophysiology
    • 1999
    • 62
    Affective modulation of the startle reflex in schizophrenic patients
    • 54
    Benzodiazepines have no effect on fear-potentiated startle in humans
    • 118