A review of the metabolism and pharmacokinetics of paroxetine in man

  title={A review of the metabolism and pharmacokinetics of paroxetine in man},
  author={C. M. Kaye and R. Haddock and P. F. Langley and G. Mellows and T. Tasker and B. Zussman and W. H. Greb},
  journal={Acta Psychiatrica Scandinavica},
  • C. M. Kaye, R. Haddock, +4 authors W. H. Greb
  • Published 1989
  • Psychology, Medicine
  • Acta Psychiatrica Scandinavica
  • Paroxetine is well absorbed from the gastrointestinal tract, and appears to undergo first‐pass metabolism which is partially saturable. Consistent with its lipophilic amine character, paroxetine is extensively distributed into tissues. Its plasma protein binding at therapeutically relevant concentrations is about 95%. Paroxetine is eliminated by metabolism involving oxidation, methylation, and conjugation. All of these factors lead to wide interindividual variation in the pharmacokinetics of… CONTINUE READING
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