A review of the incidence and coincidence of uterine and mammary tumors in Wistar and Sprague-Dawley rats based on the RITA database and the role of prolactin.

@article{Harleman2012ARO,
  title={A review of the incidence and coincidence of uterine and mammary tumors in Wistar and Sprague-Dawley rats based on the RITA database and the role of prolactin.},
  author={Johannes H. Harleman and Adam Hargreaves and H{\aa}kan Andersson and Sarah J Kirk},
  journal={Toxicologic pathology},
  year={2012},
  volume={40 6},
  pages={926-30}
}
Wistar rats are frequently selected for use in carcinogenicity studies because of their advantageous survival rate, which is more favorable than other strains such as the Sprague-Dawley (SD) strain. Uterine and mammary tumors are relatively common spontaneous neoplasms of both strains. We examined the incidence and coincidence of uterine tumors and mammary tumors in control animals of both strains within the RITA database. There was a strong inverse relationship between these tumor types in… CONTINUE READING

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