A review of the hippocampal place cells

  title={A review of the hippocampal place cells},
  author={John O’Keefe},
  journal={Progress in Neurobiology},
  • J. O’Keefe
  • Published 31 December 1979
  • Medicine, Psychology
  • Progress in Neurobiology
Cortico-Hippocampal Interplay and the Representation of Contexts in the Brain
1 Statement of the Problem.- 1 Historical Introduction.- 2 Designs for a Prototype Cerebral Cortex.- 2 Reviews Of The Experimental Evidence Relevant To The Formulation Of The Theory OfExpand
The organization of spatial coding in the hippocampus: a study of neural ensemble activity
The organization of multiple, clustered place fields with correlated movement tuning properties in small neural ensemble suggests the existence of functional neural ensembles serving to encode multiple sensory and behavioral aspects of a place or event. Expand
Effect of spatial and non-spatial changes on perceived self-location
Place cell activity is measured through single-cell recording in animals, though placeresponsive cells and related properties have been identified in the human hippocampus. Human behavioral studiesExpand
Single unit activity in the rat hippocampus during a spatial memory task
The results provide strong support for the cognitive map theory of hippocampal function and demonstrate that the representations of places within an environment are connected together to form a map, that the orientation of this map relative to an environment can be changed from trial to trial, and that this orientation is “remembered” following the removal of the controlled spatial cues. Expand
The hippocampus and space revisited
  • L. Nadel
  • Psychology, Medicine
  • Hippocampus
  • 1991
The hippocampal formation has long been the focus of intense interest among neuroscientists, and some of the themes that were important to us then, and remain so now, are dug back into in The Hippocumpiis CIS a Cognitive M a p and reiterated. Expand
Where is my reward and how do I get it? Interaction between the hippocampus and the basal ganglia during spatial learning
A new functional spatial decision network with three separate loops encompassing hippocampus and specific basal ganglia regions is proposed, which serves a different aspect of spatial decision making and all three are linked by their mutual connections and are under the control of the dopaminergic learning signal. Expand
Cholinergic modulation of the superficial layers of the parasubiculum.
Increases in cholinergic tone during network-level theta-frequency oscillations in the parasubiculum may increase neuronal excitability by exerting strong effects on postsynaptic conductances, but may also regulate network dynamics by reducing the strength of incoming afferents. Expand
Framing spatial cognition: neural representations of proximal and distal frames of reference and their roles in navigation.
The historical underpinnings of the "standard" view from a behavioral perspective are reviewed, and newer results demonstrating that an animal's behavior in such spatial tasks is more strongly controlled by a local-apparatus frame of reference than by distal landmarks are reviewed. Expand
Roles for the subiculum in spatial information processing, memory, motivation and the temporal control of behaviour
Recent data indicating that the subiculum participates in a wide range of neurocognitive functions and processes are discussed, with there appears to a strong dorso-ventral segregation of function withinSubiculum, with the dorsal subICulum relatively more concerned with space and memory, and the ventral hippocampus concerned with stress, anxiety and reward. Expand
Context-dependent modulation by D(1) receptors: differential effects in hippocampus and striatum.
Although hippocampal place field locations were altered by the contextual change, the reliability and specificity of place fields was disrupted only by combining D(1) antagonism and a change in context. Expand


Studies on single neurons in dorsal hippocampal formation and septum in unrestrained rats. II. Hippocampal slow waves and theta cell firing during bar pressing and other behaviors.
Electrode placement within the hippocampus was critical with regard to how much slow-wave theta could be recorded during voluntary behaviors, whereas theta cells throughout the hippocampus were identical in the form of their firing. Expand
First occurrence of hippocampal spatial firing in a new environment
  • A. J. Hill
  • Biology, Medicine
  • Experimental Neurology
  • 1978
Rats were pretrained to perform an operant task in a straight-line shuttle box for food reward and then transferred to a T-maze (requiring similar behavior), showing specific spatial firing immediately in 10 of 12 cases. Expand
Identification of pyramidal cells as the critical elements in hippocampal neuronal plasticity during learning.
  • T. Berger, R. F. Thompson
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1978
The major output neurons of the hippocampus appear to be the neuroanatomical substrate for the large and rapidly developing neuronal plasticity induced by this classical conditioning paradigm. Expand
Neuronal plasticity in the limbic system during classical conditioning of the rabbit nictitating membrane response. I. The hippocampus
Hippocampal unit responses were recorded throughout classical conditioning of the rabbit nictitating membrane response to a tone conditioned stimulus using a corneal air-puff unconditioned stimulus, revealing a rapidly developing increase in cell discharges within the first block of paired trials. Expand
Spatial correlates of hippocampal unit activity
Electrical activity of units in the hippocampus was recorded from freely behaving rats as they explored a spatial maze to provide strong support for the hypothesis that the hippocampus is involved in the processing of spatial information. Expand
Anatomical and functional aspects of the septo-hippocampal projections.
Good agreement is found between the distribution of hippocampal acetylcholinesterase and the patterning of silver grains after injection of [3H]leucine into the medial septum and diagonal bands and those cells labelled after injections of horseradish peroxidase into the hippocampus coincide. Expand
Responsiveness of neurones in the hippocampal region of anaesthetised and unanaesthetised cats to stimulation of sensory pathways
An important determinant of HR unit responses was the state of arousal, the effect being regionally distributed and the proportions of responding units were substantially lower and the responses were weaker than those in the unanaesthetised cats. Expand
Place units in the hippocampus of the freely moving rat
The results suggest that place units were not responding to a simple sensory stimulus nor to a specific motor behavior, and are interpreted as strong support for the cognitive map theory of hippocampal function. Expand
Sensoṙy inputs to the hippocampal place units