A review of the hippocampal place cells

@article{OKeefe1979ARO,
  title={A review of the hippocampal place cells},
  author={John O’Keefe},
  journal={Progress in Neurobiology},
  year={1979},
  volume={13},
  pages={419-439}
}
  • J. O’Keefe
  • Published 31 December 1979
  • Medicine, Psychology
  • Progress in Neurobiology
Cortico-Hippocampal Interplay and the Representation of Contexts in the Brain
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Context-dependent modulation by D(1) receptors: differential effects in hippocampus and striatum.
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Although hippocampal place field locations were altered by the contextual change, the reliability and specificity of place fields was disrupted only by combining D(1) antagonism and a change in context. Expand
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References

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Electrode placement within the hippocampus was critical with regard to how much slow-wave theta could be recorded during voluntary behaviors, whereas theta cells throughout the hippocampus were identical in the form of their firing. Expand
First occurrence of hippocampal spatial firing in a new environment
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Rats were pretrained to perform an operant task in a straight-line shuttle box for food reward and then transferred to a T-maze (requiring similar behavior), showing specific spatial firing immediately in 10 of 12 cases. Expand
Identification of pyramidal cells as the critical elements in hippocampal neuronal plasticity during learning.
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  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1978
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The major output neurons of the hippocampus appear to be the neuroanatomical substrate for the large and rapidly developing neuronal plasticity induced by this classical conditioning paradigm. Expand
Neuronal plasticity in the limbic system during classical conditioning of the rabbit nictitating membrane response. I. The hippocampus
TLDR
Hippocampal unit responses were recorded throughout classical conditioning of the rabbit nictitating membrane response to a tone conditioned stimulus using a corneal air-puff unconditioned stimulus, revealing a rapidly developing increase in cell discharges within the first block of paired trials. Expand
Spatial correlates of hippocampal unit activity
TLDR
Electrical activity of units in the hippocampus was recorded from freely behaving rats as they explored a spatial maze to provide strong support for the hypothesis that the hippocampus is involved in the processing of spatial information. Expand
Anatomical and functional aspects of the septo-hippocampal projections.
TLDR
Good agreement is found between the distribution of hippocampal acetylcholinesterase and the patterning of silver grains after injection of [3H]leucine into the medial septum and diagonal bands and those cells labelled after injections of horseradish peroxidase into the hippocampus coincide. Expand
Responsiveness of neurones in the hippocampal region of anaesthetised and unanaesthetised cats to stimulation of sensory pathways
TLDR
An important determinant of HR unit responses was the state of arousal, the effect being regionally distributed and the proportions of responding units were substantially lower and the responses were weaker than those in the unanaesthetised cats. Expand
Place units in the hippocampus of the freely moving rat
TLDR
The results suggest that place units were not responding to a simple sensory stimulus nor to a specific motor behavior, and are interpreted as strong support for the cognitive map theory of hippocampal function. Expand
Sensoṙy inputs to the hippocampal place units
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