A review of the evidence supporting melatonin's role as an antioxidant

  title={A review of the evidence supporting melatonin's role as an antioxidant},
  author={Russel Joseph Reiter and Daniela Melchiorri and Ewa Sewerynek and Burkhard Poeggeler and Lorneli Barlow‐Walden and Jih-Ing Chuang and Genaro Gabriel Ortiz and Dario Acu{\~n}aCastroviejo},
  journal={Journal of Pineal Research},
Abstract: This survey summarizes the findings, accumulated within the last 2 years, concerning melatonin's role in defending against toxic free radicals. Free radicals are chemical constituents that have an unpaired electron in their outer or‐bital and, because of this feature, are highly reactive. Inspired oxygen, which sustains life, also is harmful because up to 5% of the oxygen (O2) taken in is converted to oxygen‐free radicals. The addition of a single electron to O2 produces the… 

Significance of Melatonin in Antioxidative Defense System: Reactions and Products

Melatonin in plants not only provides an alternative exogenous source of melatonin for herbivores but also suggests that melatonin may be an important antioxidant in plants which protects them from a hostile environment that includes extreme heat, cold and pollution, all of which generate free radicals.

Cellular and Biochemical Actions of Melatonin which Protect Against Free Radicals: Role in Neurodegenerative Disorders

The mechanisms of oxidative damage and its relationship with the most highly studied neurodegenerative diseases and the roles of melatonin as free radical scavenger and neurocytoskeletal protector are described.

Melatonin as a radioprotective agent: a review.

Oxidative damage in the central nervous system: protection by melatonin

Melatonin and Its Relation to the Immune System and Inflammation

Melatonin reduces tissue destruction during inflammatory reactions by a number of means, and by virtue of its ability to directly scavenge toxic free radicals, reduces macromolecular damage in all organs.

Peroxynitrite in airway diseases

‘Free radicals’ are molecules with an unpaired electron in the outer orbital and are therefore highly reactive and important in inflammatory processes as a free radical, but possibly also as a messenger molecule.

Melatonin as a hydroxyl radical scavenger

It was possible to survey the reactions of melatonin with radiolitically generated 'OH and hydrated electron in deoxygenated water solutions using the pulse-radiolysis methods as the precise tools for studying fast reactions.

Melatonin's unique radical scavenging properties – roles of its functional substituents as revealed by a comparison with its structural analogs

Melatonin's redox chemistry is compared with that of several structural analogs, indicating that radical chain termination by O2·− is considerably more efficient with melatonin, which was much more rapidly oxidized than the 5‐hydroxylated and non‐substituted analogs.



Melatonin, hydroxyl radical‐mediated oxidative damage, and aging: A hypothesis

Experiments investigating the effects of endogenous excitatory amino acid antagonists and stimulants of melatonin biosynthesis such as magnesium may finally lead to novel therapeutic approaches for the prevention of degeneration and dysdifferentiation associated with diseases related to premature aging.

Melatonin As a Free Radical Scavenger: Implications for Aging and Age‐Related Diseases a

This recently discovered function of melatonin establishes a role for this indole in every organism, and indeed in every cell, from the most primitive members of the animal kingdom up to and including the was shown to be a hormone produced in and secreted from the mammalian pineal gland.

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

It is proposed that superoxide dismutase may protect vascular tissue stimulated to produce superoxide and NO under pathological conditions by preventing the formation of peroxynitrite.

Initiation of lipid peroxidation in biological systems.

The data reviewed indicate that lipid peroxidation is initiated by nonenzymatic and enzymatic reactions, and the generation of a superoxide radical, or its protonated molecule, the perhydroxyl radical could directly initiate PUFA per oxidation.

Free radicals in toxicology.

Free radicals are recognized more and more frequently as being involved in the mechanism of toxicity of chemicals. In some cases, the organic radicals are involved, but often oxygen radicals result

Oxygen-radical absorbance capacity assay for antioxidants.

Mechanisms of lipid peroxidation.

  • A. Girotti
  • Chemistry, Physics
    Journal of free radicals in biology & medicine
  • 1985