A review of the efficacy and safety of devil's claw for pain associated with degenerative musculoskeletal diseases, rheumatoid, and osteoarthritis.

@article{Denner2007ARO,
  title={A review of the efficacy and safety of devil's claw for pain associated with degenerative musculoskeletal diseases, rheumatoid, and osteoarthritis.},
  author={Sallie Stoltz Denner},
  journal={Holistic nursing practice},
  year={2007},
  volume={21 4},
  pages={
          203-7
        }
}
Harpagophytum procumbens, known as devil's claw, has been used traditionally for the treatment of pain, fevers, and dyspepsia. Recently, it has become popular for the treatment of rheumatoid and osteoarthritis. Studies have yet to establish a clear mechanism of action; however, current research is focusing on pro-inflammatory mediators as well as on potential antioxidant characteristics. 
Devil's Claw (Harpagophytum procumbens) as a treatment for osteoarthritis: a review of efficacy and safety.
BACKGROUND Osteoarthritis (OA) is a highly prevalent musculoskeletal disorder. Conventional treatment (i.e., the use of nonsteroidal anti-inflammatory drugs-NSAIDs) is associated with well-documented
The use of glucosamine, devil's claw (Harpagophytum procumbens), and acupuncture as complementary and alternative treatments for osteoarthritis.
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Glucosamine, Harpagophytum procumbens, and acupuncture are among the most commonly used complementary and alternative medicine approaches utilized by patients suffering from osteoarthritis and their clinical relevance, safety, and potential mechanisms of action are discussed.
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It was concluded that both the drugs are potentially safe for use and no mortality and morbidity were observed and no variation in weights were identified on either groups.
he role of Western herbal medicine in the reatment of gout
Gout has been recognised as a clinically distinct disease for over four millennia. It is one of the most prevalent inflammatory arthropathies and a true crystal deposition disease. Current consensus
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The published evidence is reviewed that reveal the anti-inflammatory effects of Hp including inhibition of key mediators and promoters of inflammation and the relevance of these effects for the therapeutic use of H p in osteoarthritis is discussed.
Osteogenic and Anti-Inflammatory Behavior of Injectable Calcium Phosphate Loaded with Therapeutic Drugs
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Phytochemical Analysis and Anti-Inflammatory and Anti-Osteoarthritic Bioactive Potential of Verbascum thapsus L. (Scrophulariaceae) Leaf Extract Evaluated in Two In Vitro Models of Inflammation and Osteoarthritis
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Verbascum thapsus leaf aqueous extract has the potential to moderate the inflammatory response, representing an innovative possible approach for the inflammatory joint disease treatment.
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References

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Devil's Claw (Harpagophytum procumbens) as a treatment for osteoarthritis: a review of efficacy and safety.
BACKGROUND Osteoarthritis (OA) is a highly prevalent musculoskeletal disorder. Conventional treatment (i.e., the use of nonsteroidal anti-inflammatory drugs-NSAIDs) is associated with well-documented
Correction: Harpagophytum procumbens for osteoarthritis and low back pain: A systematic review
After publication of this article [1], it was learned that there was an inadvertent omission of the following statement acknowledging the National Center for Complementary and Alternative Medicine
A review of the biological and potential therapeutic actions of Harpagophytum procumbens
TLDR
Analysis of the in vitro and ex vivo studies that currently exist, indicate that Hp has significant effects on numerous proinflammatory markers, however, the exact mechanism(s) by which Hp may reduce inflammation remain to be elucidated.
Antioxidant effects of herbal therapies used by patients with inflammatory bowel disease: an in vitro study
Herbal remedies used by patients for treatment of inflammatory bowel disease include slippery elm, fenugreek, devil’s claw, Mexican yam, tormentil and wei tong ning, a traditional Chinese medicine.
Evaluation of acute and chronic treatments with Harpagophytum procumbens on Freund's adjuvant-induced arthritis in rats.
TLDR
The data showed anti-inflammatory and peripheral analgesic properties of Harpagophytum procumbens extract with all doses tested, thus confirming its indication for inflammatory processes.
Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects.
TLDR
This review summarizes the efficacy and toxicities of herbal remedies used in complementary and alternative medical (CAM) therapies for rheumatologic conditions, by elucidating the immune pathways through which these preparations have antiinflammatory and/or immunomodulatory activity and providing a scientific basis for their efficacy.
Herbal Medicine for Low Back Pain: A Cochrane Review
TLDR
Harpagophytum procumbens, Salix alba, and Capsicum frutescens seem to reduce pain more than placebo, and additional trials testing these herbal medicines against standard treatments will clarify their equivalence in terms of efficacy.
The commercial harvest of devil's claw (Harpagophytum spp.) in southern Africa: the devil's in the details.
TLDR
Devil's claw is the common name for two species in the genus Harpagophytum, which has been found to be effective in the treatment of degenerative rheumatoid arthritis, osteoarthritis, tendonitis, kidney inflammation, and heart disease.
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TLDR
Though no significant intergroup differences were demonstrable, large numbers will be needed to show equivalence in a definitive comparison between Doloteffin and rofecoxib.
Devil’s Claw (Harpagophytum procumbens DC)
An evidence-based ststematic review including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interaction,
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