A review of the effects of tibolone on the skeleton

@article{Devogelaer2004ARO,
  title={A review of the effects of tibolone on the skeleton},
  author={J. Devogelaer},
  journal={Expert Opinion on Pharmacotherapy},
  year={2004},
  volume={5},
  pages={941 - 949}
}
  • J. Devogelaer
  • Published 2004
  • Medicine
  • Expert Opinion on Pharmacotherapy
Osteoporosis is a frequent condition, which can lead to significant morbidity and even to increased mortality, owing to its complications (i.e., the fractures). Several therapies, mostly antiresorbing agents such as oestrogens, antioestrogens (chiefly raloxifene), calcitonin and bisphosphonates, are recognised for the treatment of the condition. More recently, parathyroid hormone has been added to the armamentarium of therapeutic agents. However, except for oestrogens, no other therapy… Expand
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It is found that tibolone given in the early postmenopausal years suppresses skeletal metabolism and prevents bone loss in both spine and femur, and has a potentially important long-term role in the reduction of the incidence of osteoporotic fractures. Expand
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It is concluded that tibolone acts as a tissue-specific compound by mediating its effects via steroid receptors and enzymatic pathways, and avoids stimulation of the endometrium and breast tissue. Expand
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Prevention of post-oophorectomy bone loss with tibolone
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It is concluded that Tibolone is effective in the prevention of the post-ovariectomy accelerated bone loss and in retaining the initial premenopausal bone mass, at least during the first post-oophorectomy year. Expand
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