A review of the effects of shear and interfacial phenomena on cell viability.

@article{Hua1993ARO,
  title={A review of the effects of shear and interfacial phenomena on cell viability.},
  author={Jiuzhao Hua and Larry E. Erickson and T Y Yiin and Larry A. Glasgow},
  journal={Critical reviews in biotechnology},
  year={1993},
  volume={13 4},
  pages={305-28}
}
The shear sensitivity of animal and plant cells is a problem often encountered in large-scale cell culture. Such sensitivity varies with different cell lines and the severity of cellular damage may depend on both the magnitude and the duration of the shear stress. In a bioreactor, the shear susceptibility of cells depends on their response to hydrodynamic forces arising from fluid motions of particular scale. Cell damage may be induced by forces in the bulk liquid phase, but fluid motions… CONTINUE READING

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