A review of the causes of central pontine myelinosis: yet another apoptotic illness?

@article{Ashrafian2001ARO,
  title={A review of the causes of central pontine myelinosis: yet another apoptotic illness?},
  author={Houman Ashrafian and Phillip Davey},
  journal={European journal of neurology},
  year={2001},
  volume={8 2},
  pages={103-9}
}
One of the well recognized stimuli for central pontine myelinosis (CPM) is the rapid correction of chronic hyponatraemia. Conventionally this has been perceived to lead to pontine glial cell swelling through osmosis and eventually to cell death. However, although a purely osmotic argument has been central to any patho-physiological understanding of CPM, there are deficiencies in this approach that do not account for why certain individuals develop CPM with relatively mild osmotic insults. Here… CONTINUE READING
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