A review of the cardiovascular effects and toxicity of tricyclic antidepressants.

@article{Jefferson1975ARO,
  title={A review of the cardiovascular effects and toxicity of tricyclic antidepressants.},
  author={James W. Jefferson},
  journal={Psychosomatic medicine},
  year={1975},
  volume={37 2},
  pages={160-79}
}
The tricyclic antidepressants have potent and complex effects on the cardiovascular system, both directly and through interactions with other drugs. Through a combination of anticholinergic activity, direct myocardial depressant activity and an effect on the adrenergic neuron, they can cause a combination of arrhythmias, blood pressure abnormalities and congestive heart failure. These changes, although most common with overdose, can occur at therapeutic levels. In addition a number of drug-drug… CONTINUE READING

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