A review of the cardiovascular and breast actions of drospirenone in preclinical studies
@article{Simoncini2010ARO, title={A review of the cardiovascular and breast actions of drospirenone in preclinical studies}, author={Tommaso Simoncini and Andrea R Genazzani}, journal={Climacteric}, year={2010}, volume={13}, pages={22 - 33} }
Objective Hormone therapy is effective for the relief of menopausal symptoms. For women with a uterus, addition of a progestogen is required to protect the endometrium. However, synthetic progestins differ in certain pharmacological characteristics that may have implications for clinical practice. This literature-based review explores differences in the preclinical and clinical profiles of the progestins used in hormone therapy, focusing on their effects on the cardiovascular system and breast…
14 Citations
Progestogens used in postmenopausal hormone therapy: differences in their pharmacological properties, intracellular actions, and clinical effects.
- Medicine, BiologyEndocrine reviews
- 2013
Differences in chemical structure, metabolism, pharmacokinetics, affinity, potency, and efficacy via steroid receptors, intracellular action, and biological and clinical effects confirm the absence of a class effect of progestogens.
Progestogen effects at vascular level: the endothelial cells
- Biology, MedicineHormone molecular biology and clinical investigation
- 2010
The most important data from in vivo and in vitro studies which have been published on the effects of progesterone and progestogens on vascular cells are reviewed.
Effects of drospirenone and norethisterone acetate combined with estradiol on mammographic density and proliferation of breast epithelial cells-A prospective randomized trial.
- MedicineMaturitas
- 2019
Estradiol 1 mg and drospirenone 2 mg as hormone replacement therapy in postmenopausal Chinese women
- MedicineClimacteric : the journal of the International Menopause Society
- 2011
Daily treatment of postmenopausal Chinese women with DRSP/E2 for 16 weeks significantly reduced the incidence of hot flushes and demonstrated advantages vs. placebo for other climacteric symptoms.
Why sex matters: the biological mechanisms of cardiovascular disease
- Biology, MedicineGynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
- 2012
The pathophysiology of CVD in women and its potential clinical implications are reviewed, with particular emphasis on biochemical markers and to indicators of cardiovascular dysfunction and damage.
Factors affecting the choice of drospirenone as the component of combined contraceptive pill in daily clinical practice: the results of nation-wide survey.
- MedicineGinekologia polska
- 2021
Drospirenone is frequently chosen progestogen component in CCP by Polish gynecologists due to its good tolerance, consistent regulation of the menstrual cycle and no spotting in patients opinion and was most frequently used in patients with irregular menstrual cycles and painful menstruation.
One-year randomized study of the endometrial safety and bleeding pattern of 0.25 mg drospirenone/0.5 mg 17β-estradiol in postmenopausal women
- MedicineClimacteric : the journal of the International Menopause Society
- 2013
The low-dose, 0.25 mg DRSP/0.5 mg E2 dose combination met the criteria for endometrial safety and demonstrated a favorable risk/benefit profile in this 1-year, double-blind, randomized study of postmenopausal women.
Effects of hormone replacement therapy on plasma and tissue fibrinolytic activity in a rat model of surgically induced menopause.
- Medicine, BiologyClinical and investigative medicine. Medecine clinique et experimentale
- 2014
HRT showed beneficial effects by decreasing fibrinolytic activity related to surgically-induced menopause and short-term HRT treatment was associated with a shift in the procoagULant-anticoagulant balance toward a procoAGulant state.
A randomized, double-blind, placebo-controlled study of the lowest effective dose of drospirenone with 17&bgr;-estradiol for moderate to severe vasomotor symptoms in postmenopausal women
- Medicine, PsychologyMenopause
- 2014
Drospirenone 0.25 mg/17&bgr;-estradiol 0.5 mg is concluded to be the lowest dose with demonstrated efficacy in the treatment of postmenopausal women with moderate to severe vasomotor symptoms.
Latest reports on the cardiovascular safety of hormone replacement therapy
- Medicine
- 2012
W pracy dokonano przeglądu najnowszych doniesień dotyczących powikłań zakrzepowo-zatorowych, zarówno tętniczych, jak i żylnych, związanych ze stosowaniem hormonalnej terapii zastępczej (hormone…
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