A review of the actual knowledge of the processes governing growth and development of long bones.

@article{Pazzaglia2011ARO,
  title={A review of the actual knowledge of the processes governing growth and development of long bones.},
  author={Ugo E Pazzaglia and Giampiero Beluffi and Anna Benetti and Maria Pia Bondioni and Guido Zarattini},
  journal={Fetal and pediatric pathology},
  year={2011},
  volume={30 3},
  pages={199-208}
}
Autoptic samples of human bones (from 8 weeks of gestation to 12 years of age) and a second group of serial, skeletal x-rays (required for pathologies not related to bone dysplasia in children from 4 months to 17 years of age) provided the material for the analysis of the physes normal growth mechanism presented in this review. Before the appearance of the ossification centers epiphyseal growth rests exclusively on chondrocytes proliferation (interstitial growth), without any detectable… CONTINUE READING

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